Author

Yuyang Zhang

The University of MelbourneORCID 0000-0002-7651-3502Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yuyang Zhang5 papers · Army Medical University

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:diffusion model· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Adam P. UldrichiD· 1 shared Alexandra Jane CorbettiD· 1 shared Alexis Perez‐GonzaleziD· 1 shared Calvin XuiD· 1 shared Caroline SolimaniD· 1 shared Chunfu XuiD· 1 shared Dale Ian GodfreyiD· 1 shared David P. FairlieiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperImmunology

Adam P. UldrichORCID

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2 papers

Recent·Most cited

Specific targeting of MR1-antigen complexes using nanobodies

Hisham S. Hussain, Samuel J. Redmond, Wael Awad, Calvin Xu, Caroline Soliman, Huimeng Wang, Yuyang Zhang, Lisa Ciacchi, Alexis Perez‐Gonzalez, Jeffrey Y. W. Mak, David P. Fairlie, James McCluskey, Alexandra Jane Corbett, Adam P. Uldrich, Jamie Rossjohn, , Nicholas A. Gherardin

The paper develops a nanobody targeting MR1-5-OP-RU complexes and demonstrates its ability to modulate MAIT cell responses and act as a bispecific engager.

Science Immunology · Sep 25, 2026Peer-reviewedImmunology

Improving diffusion-based protein backbone generation with global-geometry-aware latent encoding

Yuyang Zhang, Yuhang Liu, Zinnia Ma, Min Li, Chunfu Xu, Haipeng Gong

This paper introduces TopoDiff, a diffusion-based framework for protein backbone generation that improves global geometry control and fold diversity through a structure encoder and latent sampler.

Nature Machine Intelligence · Jun 18, 2025Peer-reviewedBioengineering