Platelet-programmed circulating tumor cells signal to monocytes through a candidate CD40LG-ITGA5:ITGB1 myeloid checkpoint axis in breast cancer
Samane Khoshbakht, Hojat Borna, Mehrnaz Zarei, Zahra Salehi, Niloofar Hejazifar, Yasaman Setayeshpour, Niroshana Anandasabapathy, Mayte Suárez‐Fariñas
This study identifies platelet-programmed CTCs and their communication with monocytes via CD40LG-ITGA5:ITGB1, showing an inverse association with survival in breast cancer.
bioRxiv · Sep 22, 2026 · PreprintCancer Biology