Cancer BiologybioRxivPreprint
The Pregnane X Receptor (PXR) contributes to phenotypic plasticity and modulates the sensitivity to targeted therapies in melanoma
Stefan D Nicolescu, Alice Matheux, Marina Grimaldi…·Philippe Pourquier
This study shows that PXR expression in melanoma cells increases sensitivity to BRAFi/MEKi treatment and is linked to a melanocytic phenotype.
DOI 10.64898/2026.11.03.762858