Céline Gongora

This study shows that PXR expression in melanoma cells increases sensitivity to BRAFi/MEKi treatment and is linked to a melanocytic phenotype.

This paper identifies a single-chain Fv antibody that allosterically inhibits p38α MAPK by binding to a site distinct from the ATP-binding pocket, reducing inflammation in THP-1 cells.

This study identifies TopBP1 condensation inhibitors, showing AZD2858 disrupts ATR signaling and synergizes with chemotherapy in colorectal cancer.

This paper shows that inhibiting p38MAPK increases sensitivity of drug-resistant pancreatic cancer cells to chemotherapy and correlates with better patient outcomes.

This study shows that inhibiting SUV4-20H enzymes enhances the effectiveness of TOP2 poisons in prostate cancer by increasing DNA damage and impairing repair mechanisms.