Xiaohe Tian

This study shows that breast cancer polygenic risk scores perform differently across socioeconomic statuses, with income improving predictive accuracy in certain groups.

This study examines sex and race differences in LDL-C levels and statin treatment using All of Us data, finding higher LDL-C in women and lower statin use and efficacy in women, especially Black women.

PRISM improves polygenic score transferability across populations by integrating ancestry-aware tissue-specific genomic annotations, achieving a 13.10% performance boost for African ancestry.