Author

Jacob Huang

Broad InstituteORCID 0009-0005-8757-6540Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Andreas R. GschwindiD· 2 shared Dulguun AmgalaniD· 2 shared Evelyn Jagoda· 2 shared Glen Munson· 2 shared J EngreitziD· 2 shared James GalanteiD· 2 shared Judhajeet RayiD· 2 shared Lars Michael SteinmetziD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Andreas R. GschwindORCID

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2 papers

Recent·Most cited

GeneticsNature GeneticsPeer-reviewedAug 1, 2026

Mapping enhancer-gene regulatory interactions from single-cell data

Maya U. Sheth, Wei‐Lin Qiu, X. Rosa Ma…·Robin Andersson

The paper introduces scE2G models to predict enhancer-gene regulatory interactions from single-cell data and demonstrates their performance across multiple cell types and perturbations.

29 citationstop 1%

humanATAC-seq

𝕏 PostBluesky

GenomicsbioRxivPreprintSep 16, 2025

A systematic survey of distal element-gene regulatory interactions with Direct-Capture Targeted Perturb-seq

Judhajeet Ray, Evelyn Jagoda, Maya U. Sheth…·J Engreitz

This study identifies most distal element-gene interactions have small effect sizes (<10%) using DC-TAP-seq, revealing limitations in prior CRISPR screens and suggesting new model requirements.

5 citations

humanCRISPR screen

𝕏 PostBluesky