Author

Lei Jin

University of MissouriORCID 0009-0006-2624-7732Unclaimed ORCID profile · follow to get notified of new preprints

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Lei Jin1 paper

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Approach:machine learning (classical)· 1 Research Focus:protein folding & dynamics· 1

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Dongsheng DuaniD· 1 shared Risi LiyanageiD· 1 shared Shi‐Jie CheniD· 1 shared

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Dongsheng DuanORCID

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1 paper

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BiophysicsPRX LifePeer-reviewedFeb 4, 2026

Machine learning-inferred and energy landscape-guided analyses reveal kinetic determinants of CRISPR/Cas9 gene editing

Lei Jin, Risi Liyanage, Dongsheng Duan, Shi‐Jie Chen

This study combines machine learning and energy landscape analysis to identify kinetic determinants of CRISPR/Cas9 gene editing, revealing a three-state mechanism and critical nucleotides for cleavage efficiency.

1 citation

machine learning (classical)protein folding & dynamics

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