Lineage-specific X chromosome inactivation escape and skew underlie sex-biased immune gene dosage and deleterious variant exposure
Daisy Kavanagh, Alice Steel, Helen E. King…·Ksenia Skvortsova
This paper introduces scDaisyChain to analyze X chromosome inactivation escape and skew in immune cells, revealing lineage-specific effects on gene dosage and variant exposure in healthy and autoimmune disease contexts.