Yūki Ichikawa

The paper analyzes why LD measures disagree in the rare-common regime by examining the geometric structure of the haplotype simplex under the Fisher information metric.

The paper analyzes carrier-set topology in linkage disequilibrium using empirical data and a Wright-Fisher model, showing that topology and visibility are separable and that |D'| better distinguishes nested configurations than r2.

The paper identifies composite MHC tagging at the MICA rs2596542 locus using carrier-set topology and NMF, revealing separable regulatory haplotypic backgrounds.

The paper investigates the role of PIWI/piRNA in somatic tissues of the pearl oyster Pinctada fucata, showing that piRNA0001 regulates hundreds of endogenous genes through differential expression.