Author

Robin Bruce Thacker

ORCID 0009-0007-3494-7525Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Organism:E. coli· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Activity by Year

2026-2026 · peak 1/yr

1 paper

Recent·Most cited

BioinformaticsbioRxivPreprintMar 5, 2026

Confidence Without Verification: Screening pLDDT Unreliability in AlphaFold2 Fold-Switching Predictions

Robin Bruce Thacker

The paper identifies unreliable confidence metrics in AlphaFold2 predictions for fold-switching proteins and introduces a screening method to detect false positives.

DOI 10.64898/2026.02.19.706878

E. coliprotein structure

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