ProtCell: a foundation model for single-cell proteomics
Bowen Hu, Zhen Li, Qun Jiang…·Rui Jiang
ProtCell connects fragmented proteomic profiles, extends information beyond measured panels, and guides more informative measurements.
Author
Beijing National Research Center for Information Science and TechnologyORCID 0009-0007-5442-7906Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
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Bowen Hu, Zhen Li, Qun Jiang…·Rui Jiang
ProtCell connects fragmented proteomic profiles, extends information beyond measured panels, and guides more informative measurements.
Keyi Li, Xiaoyang Chen, Qun Jiang…·Rui Jiang
EpiZoo is a cross-species single-cell epigenomic foundation model that uses DNA sequence-aware architecture to improve cell type annotation and mutation prioritization across species.
Qun Jiang, Zhen Li, Bowen Hu…·Qijin Yin
HoloCell is a generative foundation model that integrates epigenomics, transcriptomics, and proteomics data across single-cell multi-omics modalities, demonstrating superior performance in representation learning and cross-modal generation.
Qun Jiang, Xing Ye, Zekun Guo…·Sida Shao
GEMGen generates small molecules from transcriptomic data to phenocopy gene knockdown effects and identify novel inhibitors.
Xiaoyang Chen, Zijing Gao, Keyi Li…·Rui Jiang
The paper introduces Human-scATAC-Corpus, a database of human scATAC-seq data, and presents a foundation model for epigenomic analysis.
Xiaoyang Chen, Keyi Li, Xuejian Cui…·Rui Jiang
EpiAgent is a foundation model for single-cell epigenomic data that excels in feature extraction, cell annotation, and data imputation.
Xiaoyang Chen, Keyi Li, Xiaoqing Wu…·Rui Jiang
This paper introduces Descartes, a model for identifying spatially variable chromatin accessibility peaks using inter-cellular correlations, showing improved performance and efficiency over existing methods.
Zijing Gao, Xiaoyang Chen, Zhen Li…·Rui Jiang
scEpiTools is a database that organizes and recommends tools for analyzing single-cell epigenomic data, including an ensemble method for chromatin accessibility analysis.