Pierre-Guillaume Brun

The paper introduces MEMAR, a Maximum Entropy model for predicting m6A methylation in human transcripts and influenza A viral segments, showing improved performance over existing methods.

The paper designs mutational paths for WW domains to switch specificity using computational methods and validates them experimentally, showing high success rates for structured paths over random ones.

This study uses protein resurrection and ancestral reconstruction to show that Alvinellid worms' last common ancestor had highly stable proteins, similar to modern thermotolerant species, revealing how they diversified into thermal niches.