Author

Ruohan Huang

Yale UniversityORCID 0009-0007-8244-739XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:benchmarking· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Zhongwei HuangiD· 2 shared Jinquan Han· 1 shared

Activity by Year

2026-2026 · peak 2/yr

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2 top collaborators · 1 mutual co-author link

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2 shared papersBioinformatics

Zhongwei HuangORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintOct 30, 2026

Negative sampling shapes benchmark discrimination and experimental retrieval in synthetic-lethality prediction

Zhongwei Huang, Ruohan Huang

The paper evaluates how negative sampling affects synthetic-lethality prediction models, showing that benchmark performance does not reliably predict experimental retrieval success.

DOI 10.64898/2026.10.25.761509

statistical modelbenchmark study

𝕏 PostBluesky

GenomicsbioRxivPreprintOct 13, 2026

Response representation shapes AlphaGenome enhancer-gene prediction in human astrocytes

Zhongwei Huang, Ruohan Huang, Jinquan Han

The paper evaluates how response representation affects enhancer-gene prediction in human astrocytes using CRISPR-interference data and finds that whole-enhancer deletion responses improve prediction performance.

DOI 10.64898/2026.08.14.744988

humanCRISPR screen

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