Brigitte Kühnel

This study identifies 43 genomic loci associated with reproductive success in 785,604 individuals, showing ongoing natural selection at the FADS locus.

This study identifies DNA methylation sites associated with coffee and tea consumption using EWAS, finding potential links to fatty liver disease through PHGDH expression.

The paper identifies novel genetic loci associated with blood pressure that interact with sleep duration across multiple ancestries.

DeepWAS integrates regulatory effect predictions of variants into GWAS to identify regulatory SNPs associated with diseases and traits.

The paper identifies 49 novel blood lipid loci associated with gene-sleep interactions in 126,926 individuals across 5 ancestry groups, with gene-short-sleep interactions explaining 4.25% of triglyceride variance.

The paper quantifies genetic architecture differences between European-Americans and African-Americans for four traits using random-effect interaction models, finding significant effect heterogeneity.