GeneticsThe American Journal of Human GeneticsPeer-reviewed
Beyond Exons: Linking Noncoding Heritability and Polygenicity across Complex Human Traits and Disorders
Julian Fuhrer, Alexey A. Shadrin, Timothy Hughes…·Oleksandr Frei
The paper quantifies how heritability is distributed across genomic regions for different polygenicity levels in complex traits, showing exons contribute less and intergenic regions more in highly polygenic traits.
DOI 10.1016/j.ajhg.2026.08.012