Timothy Hughes

The paper identifies extensive interactions among C2H2 zinc finger proteins at chromatin loop anchors using ChIP-seq, interactome data, and chromatin interaction maps.

This study conjugates bexarotene to dextrin to improve its solubility and in vitro potency but finds it does not reduce lipid toxicity in vivo.

The paper quantifies how heritability is distributed across genomic regions for different polygenicity levels in complex traits, showing exons contribute less and intergenic regions more in highly polygenic traits.

The paper uses GHT-SELEX to show many human TFs have high intrinsic sequence specificity and complex DNA binding, often matching in vivo ChIP-seq results.

This study shows that MCMV infection accelerates AD-like features in mice, with T cell responses playing a key role in disease progression.

The paper estimates bone marrow adiposity from head MRI scans and identifies its genetic architecture, revealing heritability, 41 genetic loci, and correlations with cognitive ability and Parkinson's disease.

This study uses a human iPSC-derived astrocyte model to identify SCZ-specific transcriptomic and functional changes in astrocytes, revealing altered gene expression and biological processes.

The paper investigates the association between predicted brain C4A expression and cognitive performance and brain imaging measures in the UK Biobank, finding significant negative associations and structural mediation effects.