NeurosciencebioRxivPreprint
Sperrfy the brain: A data-driven realization of Sperry's Chemoaffinity theory in the neural connectome
Jigen Koike, Yuichiro Yada, Riichiro Hira, Honda Naoki
SPERRFY applies Sperry's chemoaffinity theory to whole-brain connectivity using spatial transcriptomics and connectomic data, revealing positional gradients that predict axonal wiring with high accuracy.
DOI 10.1101/2025.04.30.651442