This study investigates the spatiotemporal dynamics and role of podoplanin-positive cells in fetal femur development, finding they contribute to coordinated bone formation.

Scientific Reports · Apr 19, 2026Peer-reviewedCell Biology

PDPN/CLEC-2 axis modulates megakaryocyte subtypes in a hematopoietic stem cell-regulating megakaryocyte-dominant manner

Rikuto Nara, Hinako Notoh, Tomoyuki Sasaki, Nagaharu Tsukiji, Toshiaki Shirai, Ayuka Kamata, Nobuaki Suzuki, Atsuo Suzuki, Shuichi Okamoto, Takeshi Kanematsu, Naruko Suzuki, Akira Katsumi, Tetsuhito Kojima, Katsue Suzuki‐Inoue, Tadashi Matsushita, Shogo Tamura

The paper investigates how the PDPN/CLEC-2 axis influences megakaryocyte subtypes, finding that it increases HSC-regulating megakaryocytes and decreases platelet-producing ones.

Thrombosis Research · Aug 14, 2024Peer-reviewedCell Biology

Periosteum-derived podoplanin-expressing stromal cells regulate nascent vascularization during epiphyseal marrow development

Shogo Tamura, Masato Mukaide, Yumi Katsuragi, Wataru Fujii, Koya Odaira, Nobuaki Suzuki, Nagaharu Tsukiji, Shuichi Okamoto, Atsuo Suzuki, Takeshi Kanematsu, Akira Katsumi, Akira Takagi, Katsuhide Ikeda, Jun Ueyama, Masaaki Hirayama, , Fumihiko Hayakawa

This study shows periosteum-derived podoplanin-expressing stromal cells regulate vascularization during postnatal epiphyseal marrow development by maintaining vascular integrity.

Journal of Biological Chemistry · Mar 15, 2022Peer-reviewedDevelopmental Biology