Author

Austin D. Hartley

Pennsylvania State UniversityORCID 0009-0009-0019-9295Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Costas D. MaranasiD· 1 shared Veda Sheersh BoorlaiD· 1 shared Vikas UpadhyayiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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1 shared paperBiochemistry

Costas D. MaranasORCID

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1 paper

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedApr 29, 2026

MechFind: A computational framework for de novo prediction of enzyme mechanisms

Austin D. Hartley, Vikas Upadhyay, Veda Sheersh Boorla, Costas D. Maranas

MechFind predicts enzyme mechanisms from reaction stoichiometry, achieving 72% accuracy on a training set and generating 18,000 novel hypotheses across 28,412 reactions.

3 citationstop 5%

deep learningstatistical model

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