Author

Zhuyang Lin

North Carolina State UniversityORCID 0009-0009-0480-7024Unclaimed ORCID profile · follow to get notified of new preprints

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Biophysics· 1

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Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

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Irene SilvernailiD· 1 shared Xingcheng LiniD· 1 shared Yafan ZhangiD· 1 shared

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1 shared paperBiophysics

Irene SilvernailORCID

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1 paper

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BiophysicsbioRxivMay 26, 2024

Interpretable Protein-DNA Interactions Captured by Structure-Sequence Optimization

Yafan Zhang, Irene Silvernail, Zhuyang Lin, Xingcheng Lin

The paper introduces IDEA, a model that predicts DNA recognition sites and binding affinities using structure-sequence optimization, enabling physicochemical interpretation of protein-DNA interactions.

4 citations

DNA methylationChIP-seq

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