Alan G Holt

This study uses simulation models to show that high rates of mitochondrial DNA mixing increase neuron loss and dementia risk, but selective mitophagy can prevent this, contradicting observations of normal aging.

This study simulates mitochondrial dynamics at altitude to show reduced neuron loss and cognitive decline associated with high-altitude living.

This paper simulates the effects of an uncoupling agent on dementia by modeling mitochondrial deletion mutants in human neurons, showing reduced dementia severity but increased pre-onset cognitive dysfunction.

This study simulates three mtDNA deletion proliferation mechanisms to assess their impact on neuron loss and heteroplasmy levels at dementia-associated mutation rates.