Evgeny Kiner

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

The paper evaluates deconvolution methods for bulk RNA-Seq using scnRNA-Seq data, identifies biases, and introduces SQUID, a method that outperforms others in predicting cell mixtures and identifying cancer subclones.