Alexander M. Tsankov

This study identifies Wnt9b-Sfrp2 crosstalk between endothelial and stellate cells as a driver of fibrosis resolution in MASH using single-cell and spatial profiling.

The paper identifies NRF2-driven myeloid progenitor dysregulation that sustains immunosuppressive macrophages in tumors, showing NRF2 inhibition reduces their survival and enhances antitumor immunity.

This study uses single-cell chromatin accessibility data and machine learning to predict cancer cell origins, revealing new insights into tumor development and challenging existing views on cancer origins.

This study develops a method to generate diverse GABAergic neurons from PSCs using TFs and signaling inhibition, showing distinct subtype compositions and disease relevance.

This paper develops a novel mouse model showing NOTCH1 drives temporal plasticity and metastasis in hepatocellular carcinoma through angiogenesis and TGFβ pathways.

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

This study uses single-nucleus and spatial transcriptomics to analyze pancreatic cancer before and after neoadjuvant treatment, revealing changes in cell states and immune infiltration that may inform therapy.

The paper develops a toolbox for scRNA-Seq and snRNA-Seq of fresh and frozen human tumors, testing it across eight tumor types and optimizing protocols for different tissue characteristics.