Aperiodic EEG Activity Provides a Linear, Bidirectional, and Spatially Uniform Marker of Subjective and Objective Vigilance in Humans, Both Within and Across States

Abstract

1Vigilance is increasingly conceived as a continuum, ranging from full alertness to deep sleep. Despite its fundamental role in cognition, behaviour, and health, reliable physiological markers of vigilance remain limited, and clinical assessments often rely on subjective or time-consuming evaluations. Traditionally, vigilance has been estimated through visual inspection of the electroencephalogram (EEG), identifying recognizable oscillatory patterns like rapid, wakefulness-defining alpha waves ([~]10 Hz) and large slow waves ([~]1 Hz) which typify sleep. However, these oscillatory features often appear only intermittently and follow complex, non-linear trajectories across time, space, and frequency, limiting their utility for automated, continuous tracking of vigilance. Recent research has shifted attention to the non-oscillatory, or aperiodic, component of the EEG, which may follow simpler dynamics and offer a more robust index of brain state. Yet most studies often continue to use narrowly defined, discrete vigilance states and transitions in only one direction (e.g., from wakefulness to sleep), without jointly examining oscillatory and aperiodic activity. Here, we address these key gaps by evaluating the capacity of both oscillatory and aperiodic features of EEG power spectra, derived from high-density recordings, to predict vigilance as a continuous variable. Across three independent datasets, we consistently show that although oscillatory features reliably track changes in vigilance, they are unequivocally outperformed by aperiodic activity. Aperiodic features demonstrate a stronger, more linear, and spatially consistent relationship with both objective and subjective indices of vigilance, offering a more robust and scalable physiological marker of this fundamental feature of the brain. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=173 SRC="FIGDIR/small/673229v1_ufig1.gif" ALT="Figure 1"> View larger version (28K): org.highwire.dtl.DTLVardef@1c66d88org.highwire.dtl.DTLVardef@4126b0org.highwire.dtl.DTLVardef@152f10borg.highwire.dtl.DTLVardef@4f413f_HPS_FORMAT_FIGEXP M_FIG C_FIG