The GL Service: Web Service to Exchange GL String Encoded HLA & KIR Genotypes With Complete and Accurate Allele and Genotype Ambiguity
Robert P Milius, Michael Heuer, Mike George, Jane Pollack, Jill A Hollenbach, Steven J Mack, Martin Maiers
Abstract
Genotype List (GL) Strings use a set of hierarchical character delimiters to represent allele and genotype ambiguity in HLA and KIR genotypes in a complete and accurate fashion. A RESTful web service called Genotype List Service was created to allow users to register a GL String and receive a unique identifier for that string in the form of a URI. By exchanging URIs and dereferencing them through the GL Service, users can easily transmit HLA genotypes in a variety of useful formats. The GL Service was developed to be secure, scalable, and persistent. An instance of the GL Service is configured with a nomenclature and can be run in strict or non-strict modes. Strict mode requires alleles used in the GL String to be present in the allele database using the fully qualified nomenclature. Non-strict mode allows any GL String to be registered as long as it is syntactically correct. The GL Service source code is free and open source software, distributed under the GNU Lesser General Public License (LGPL) version 3 or later.\n\nAbbreviations\n\nAbbreviations
02 /Specification & Classification
Click any tag to browse matching papers- Research Focus
- Approach
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Histoimmunogenetics Markup Language 1.0: Reporting Next Generation Sequencing-based HLA and KIR Genotyping
Robert P Milius, Michael Heuer, … Martin Maiers·Human ImmunologyPeer-reviewed·Dec 1, 2015
- A GENE FEATURE ENUMERATION APPROACH FOR DESCRIBING HLA ALLELE POLYMORPHISM
Steven J. Mack·bioRxiv·Feb 15, 2015
- glactools: a command-line toolset for the management of genotype likelihoods and allele counts
Gabriel Renaud·BioinformaticsPeer-reviewed·Nov 24, 2017
- SOAPTyping: an open-source and cross-platform tool for Sanger sequence-based typing for HLA class I and II alleles
Yong Zhang, Yongsheng Chen, … Lin Fang·BMC BioinformaticsPeer-reviewed·Jul 8, 2020
- Minimum Information for Reporting Next Generation Sequence Genotyping (MIRING): Guidelines for Reporting HLA and KIR Genotyping via Next Generation Sequencing
Steven J. Mack, Robert P Milius, … Martin Maiers·bioRxiv·Sep 24, 2015
- HLA-MA: Simple yet powerful matching of samples using HLA typing results
Clemens Messerschmidt, Manuel Holtgrewe, Dieter Beule·BioinformaticsPeer-reviewed·Mar 9, 2017