OpenDrive: An Open-Source Microdrive for Large-Scale Neurophysiology

Neuropixels-NHP probes have ushered in a new era of high-density neurophysiology recording in large animal models. Here, we present OpenDrive, an open-source microdrive system designed specifically for acute insertion of Neuropixels-NHPs. OpenDrive combines a custom motorized microdrive, six-drive control console, and software platform. Compared with commercially available options, OpenDrive offers (1) low cost, (2) precise, accurate, and stable probe movement, (3) scalability to many-probe recording, and (4) open-source hardware designs and software. In our experiments, OpenDrive has already supported recordings from thousands of neurons across a variety of cortical and subcortical structures. By lowering technical barriers and enabling community-driven development with OpenDrive, we aim to accelerate Neuropixels recording in large animal models.