bioRxivNeurosciencePreprint
Aging Impairs Temporal Integration in Supragranular but Not Thalamorecipient Layers of Primary Auditory Cortex
- Citations
- 0
Abstract
Speech has harmonic features and speech perception is impaired in aging. Imaging of auditory cortex (A1) in aged mice shows reduced selectivity to harmonic sounds and impaired temporal integration of component frequencies especially in layers 2/3 but not layer 4, suggesting that age-related changes in intracortical processing contribute to the hearing deficits. Since complex sounds can be decoded from aging A1, paradigms enhancing cortical processing might improve hearing in aging.
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- The effects of aging on neural signatures of temporal regularity processing in sounds
Björn Herrmann, Chad Buckland, Ingrid S. Johnsrude·bioRxiv·Jan 17, 2019
- Temporal selectivity declines in the aging human auditory cortex
Julia Erb, Lea‐Maria Schmitt, Jonas Obleser·eLifePeer-reviewed·Jul 3, 2020
- Cortical compensation for hearing loss, but not age, in neural tracking of the fundamental frequency of the voice
Jana Van Canneyt, Jan M Wouters, Tom Francart·Journal of NeurophysiologyPeer-reviewed·Jul 7, 2021
- Representation of speech in noise in the aging midbrain and cortex: aging may dominate over hearing-loss
Alessandro Presacco, Jonathan Z. Simon, Samira Anderson·bioRxiv·Oct 31, 2017
- Age-related auditory nerve deficits propagate central gain throughout the auditory system: Associations with cortical microstructure and speech recognition
Emily M. Fabrizio-Stover, James William Dias, … Kelly Carney Harris·Neurobiology of AgingPeer-reviewed·Nov 3, 2025
- Effects of Aging on Cortical Representations of Continuous Speech
I. M. Dushyanthi Karunathilake, Jason L. Dunlap, … Jonathan Z. Simon·Journal of NeurophysiologyPeer-reviewed·Apr 25, 2023