Patrick O. Kanold

This study investigates the responses of layer 6 corticothalamic neurons in mice during active and passive listening, revealing context-dependent gain control mechanisms in noisy environments.

This paper introduces a framework to extract directional functional interactions between neurons, stimuli, and behavior from two-photon calcium imaging data, revealing distinct sensori-behavioral roles in the mouse auditory cortex.

The paper shows that co-tuned neuronal ensembles in the auditory cortex rapidly rebalance their activity in response to stimulation to maintain consistent perceptual processing.

The paper develops a new motif detection algorithm to analyze neural activity in auditory cortex, revealing parallel encoding schemes at single neuron and population levels.

The paper investigates harmonic sound processing in auditory cortex layers, finding harmonic-sensitive neurons in A1 L4 with robust spectral integration and non-linear processing.

The paper defines deep layer 6 excitatory neurons in mouse neocortex by comparing molecular, transcriptional, morphological, and transgenic approaches, identifying a core population with distinct connectivity and developmental properties.

This study identifies gene regulatory networks controlling hypothalamic and prethalamic development using single-cell RNA and ATAC sequencing in mice, revealing key transcription factors and their roles in metabolic and cognitive traits.

This study investigates age-related changes in the auditory cortex of mice, finding reduced excitatory bandwidth, altered spectral tuning diversity, and weakened sideband inhibition in L2/3 neurons.

This study investigates hierarchical prediction error signaling in the auditory cortex of awake mice by comparing responses to simple and complex sound pattern violations.

This paper presents a method to reduce hearing loss in transgenic mice by crossing them with congenic B6.CAST-Cdh23Ahl+mice, improving auditory research accuracy.

This study examines age-related changes in excitatory and inhibitory circuits in the auditory cortex of male and female mice, finding sex-specific reductions in connectivity.

The paper investigates auditory memory for complex sounds by analyzing neural activity in different auditory cortex subregions in mice, finding memory signatures and synchronized activity in input layers.

The paper shows that dark exposure improves high-frequency sound detection in aging C57BL/6J mice and enhances auditory performance in CBA mice.

NeuroWRAP integrates and evaluates multiphoton calcium imaging analysis workflows to improve reproducibility and collaboration by combining existing algorithms and enabling custom workflows.

The paper measures redundant and synergistic functional connectivity in mouse auditory cortex during a perceptual task, finding that connected neuron pairs show more redundancy and less synergy than unconnected pairs.

The paper shows that some neurons in the mouse primary auditory cortex encode the mismatch between action and sound, revealing hierarchical integration of sensory and action signals.

The paper uses BARseq to analyze transcriptomic signatures in mouse cortex, showing that cell type composition defines area identity and is shaped by peripheral inputs.

The paper shows that in deaf mice lacking connexin 26, cochlear supporting cells retain spontaneous activity, preserving early auditory circuit development despite structural cochlear changes.

This paper introduces SLED, a splicing-based method to control gene expression in specific cell types, demonstrating its utility in targeting neurons, photoreceptors, and cancer cells.

The paper investigates how neuronal networks in mouse auditory cortex encode behavioral choice during pure-tone discrimination tasks, finding that specialized neurons transmit task-relevant information sequentially.

This work proposes a method to directly estimate signal and noise correlations from two-photon calcium imaging data without spike deconvolution, validated on simulated and mouse auditory cortex data.

The paper compares neuronal frequency preference and sound-level sensitivity in the primary auditory cortex of C57BL/6 and CBAxC57 F1 mice using in vivo 2-photon imaging.

This study shows that mild hypomyelination reduces parvalbumin interneuron density and inhibitory function in the auditory cortex without affecting excitatory connections.

The paper investigates intracortical connectivity to layer 1 (L1) neurons in mouse auditory cortex across development, showing transient hyperconnectivity during the critical period.

This study shows that perinatal fentanyl exposure in mice leads to somatic withdrawal and lifelong neurobehavioral changes similar to human neonatal opioid withdrawal syndrome.

This study shows that LRx in amblyopic mice induces MMP2/9 activity and ECM degradation in V1, enabling synaptic plasticity through homeostatic regulation of proteolysis.

This study examines neuronal activity in auditory cortex layers L4 and L2/3 of mice, finding that both spontaneous and evoked activity exhibit neuronal avalanches with similar power law distributions across sound levels.