The influence of trait intolerance of uncertainty on behavioural flexibility

Identifying and responding adaptively to a change in our environment is an essential skill. However, differences in our ability to detect and our disposition to react to these changes mean that some individuals are better equipped to deal with change than others. Here, we investigate whether intolerance of uncertainty, a transdiagnostic dimension of psychopathology, is associated with performance during a reversal learning task. We assessed task performance of 145 subjects using behavioural measures and computational modelling across two time points (approximately 12 days apart). Intolerance of uncertainty and its prospective and inhibitory subscales were associated with task performance, irrespective of self-reported levels of trait anxiety. Intolerance of uncertainty and its inhibitory subscale were positively associated with increased sensitivity to reinforcement from positive, but not negative, feedback. Furthermore, the inhibitory subscale was positively associated with better performance, both overall (as indexed by accuracy) and immediately following a change in reward contingencies (as indexed by perseveration). Lastly, the prospective subscale interacted with the extent to which choice was driven by expected value across time points. These findings provide novel evidence for how trait intolerance of uncertainty may modulate behavioural flexibility in changeable environments. The study points towards exciting avenues for further research into the development of IU-related behaviours across the lifespan and their implications for mental health.