Anastasia Christakou

The influence of trait intolerance of uncertainty on behavioural flexibility

This study examines how intolerance of uncertainty affects behavioural flexibility in a reversal learning task, finding associations with reinforcement sensitivity and performance following reward changes.

Evidence for direct control of neurovascular function by circulating platelets in healthy older adults

This study shows a direct link between platelet reactivity and neurovascular function in older adults, independent of vascular reactivity, suggesting a novel mechanism in early dementia pathophysiology.

Dissociable roles for the striatal cholinergic system in different flexibility contexts.

This study examines the relationship between the resting state of the dorsal striatal cholinergic system and flexible behavior in reversal learning, finding variability in choline levels correlates with error rates and learning speed.

Cortical and thalamic influences on striatal involvement in instructed, serial reversal learning; implications for the organisation of flexible behaviour.

This study investigates corticostriatal and thalamostriatal connectivity during serial reversal learning, finding increased functional connectivity between the centromedian-parafascicular nuclei and striatum for negative feedback.

Analysis of structural brain asymmetries in Attention-Deficit/Hyperactivity Disorder in 39 datasets

This study analyzes structural brain asymmetries in ADHD using 39 datasets, finding small effects that do not meet study-wide significance thresholds.

Evidence for Similar Structural Brain Anomalies in Youth and Adult Attention-Deficit/Hyperactivity Disorder: A Machine Learning Analysis

This study uses machine learning to show that structural brain anomalies in ADHD are similar in children and adults, supporting continuity of the disorder's pathophysiology.

Orbitofrontal and Thalamic Influences on Striatal Involvement in Human Reversal Learning

This study uses fMRI and PPI analysis to show that striatal connectivity with lateral orbitofrontal cortex and CM-Pf thalamus differs in their association with speed and quality of reversal learning in humans.

Subcortical brain volume, regional cortical thickness and cortical surface area across attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD): findings from the ENIGMA-ADHD, -ASD, and -OCD working groups

This study compares structural brain differences across ADHD, ASD, and OCD using MRI data from multiple cohorts, finding disorder-specific alterations in brain volume and cortical thickness.

Multimodal evidence for delayed fear extinction in adolescence and young adulthood.

This study finds that younger age is associated with greater amygdala activity and delayed mPFC engagement during fear extinction, mediated by structural integrity of the uncinate fasciculus.

Regional Striatal Cholinergic Involvement in Human Behavioural Flexibility

This study shows that dorsal striatal choline levels are linked to reversal learning performance in humans, supporting the role of the cholinergic system in behavioural flexibility.