A Non-negative Measure Of Feature-specific Information Transfer Between Neural Signals

Abstract

Quantifying both the amount and content of the information transferred between neuronal populations is crucial to understand brain functions. Traditional data-driven methods based on Wiener-Granger causality quantify information transferred between neuronal signals, but do not reveal whether transmission of information refers to one specific feature of external stimuli or another. Here, we developed a new measure called Feature-specific Information Transfer (FIT), that quantifies the amount of information transferred between neuronal signals about specific stimulus features. The FIT quantifies the feature-related information carried by a receiver that was previously carried by a sender, but that was never carried by the receiver earlier. We tested the FIT on simulated data in various scenarios. We found that, unlike previous measures, FIT successfully disambiguated genuine feature-specific communication from non-feature specific communication, from external confounding inputs and synergistic interactions. Moreover, the FIT had enhanced temporal sensitivity that facilitates the estimation of the directionality of transfer and the communication delay between neuronal signals. We validated the FITs ability to track feature-specific information flow using neurophysiological data. In human electroencephalographic data acquired during a face detection task, the FIT demonstrated that information about the eye in face pictures flowed from the hemisphere contralateral to the eye to the ipsilateral one. In multi-unit activity recorded from thalamic nuclei and primary sensory cortices of rats during multimodal stimulation, FIT, unlike Wiener-Granger methods, credibly detected both the direction of information flow and the sensory features about which information was transmitted. In human cortical high-gamma activity recorded with magnetoencephalography during visuomotor mapping, FIT showed that visuomotor-related information flowed from superior parietal to premotor areas. Our work suggests that the FIT measure has the potential to uncover previously hidden feature-specific information transfer in neuronal recordings and to provide a better understanding of brain communication. Author summaryThe emergence of coherent percepts and behavior relies on the processing and flow of information about sensory features, such as the color or shape of an object, across different areas of the brain. To understand how computations within the brain lead to the emergence of these functions, we need to map the flow of information about each specific feature. Traditional methods, such as those based on Wiener-Granger causality, quantify whether information is transmitted from one brain area to another, but do not reveal if the information being transmitted is about a certain feature or another feature. Here, we develop a new mathematical technique for the analysis of brain activity recordings, called Feature-specific Information Transfer (FIT), that can reveal not only if any information is being transmitted across areas, but whether or not such transmitted information is about a certain sensory feature. We validate the method with both simulated and real neuronal data, showing its power in detecting the presence of feature-specific information transmission, as well as the timing and directionality of this transfer. This work provides a tool of high potential significance to map sensory information processing in the brain.