Ileana L. Hanganu‐Opatz

Mapping prefrontal afferents along development

This study maps the development of prefrontal afferents from neonatal to adult stages, showing shifts in projection density and myelination patterns.

Developmental embedding of parvalbumin interneurons drives local and crosshemispheric prefrontal gamma synchrony

The paper investigates how parvalbumin interneurons contribute to the development of gamma oscillations and crosshemispheric synchrony in the prefrontal cortex during aging.

Protosequences in brain organoids model intrinsic brain states

This study shows that structured firing sequences emerge in human and murine brain organoids and neonatal brain slices, suggesting innate rather than experience-dependent neural coding.

iSTTC: a robust method for accurate estimation of intrinsic neural timescales from single-unit recordings

This paper introduces iSTTC, a method for accurately estimating intrinsic neural timescales from single-unit recordings, showing improved accuracy and robustness compared to existing methods.

Developmental olfactory dysfunction and abnormal odor memory in immune-challenged Disc1+/- mice

The paper investigates how immune challenges in Disc1+/- mice affect olfactory bulb activity and lead to memory impairments in the hippocampal-prefrontal network.

Blood pressure pulsations modulate olfactory bulb neuronal activity via mechanosensitive ion channels

A developmental increase of inhibition promotes the emergence of hippocampal ripples

This study shows that inhibition matures to promote hippocampal ripple emergence starting from postnatal day 10 in mice.

Extreme distributions in the preconfigured developing brain

The paper investigates the distribution of neural activity in the developing mouse brain and finds that extreme distributions are preconfigured and not experience-dependent.

Olfactory-driven beta band entrainment of limbic circuitry during neonatal development

This study shows that olfactory bulb activity synchronizes limbic circuits in the beta frequency range during neonatal development, shaping communication in the lateral entorhinal cortex, hippocampus, and prefrontal cortex.

An information-theoretic quantification of the content of communication between brain regions

This paper introduces a new information-theoretic measure, FIT, to quantify feature-specific information transfer between brain regions using simulated and empirical neural data.

Developmental increase of inhibition drives decorrelation of neural activity

The paper shows that increased inhibition during development drives the decorrelation of neural activity in mice and humans, linking it to neurodevelopmental disorders.

Generation and propagation of network bursts in the basal ganglia exhibit dynamic changes during early postnatal development

The paper describes two types of bursting activity in the developing basal ganglia of mice and shows their developmental changes and interactions across brain regions.

Anesthetics fragment hippocampal network activity, alter spine dynamics and affect memory consolidation

This study examines how different anesthetics affect hippocampal network activity, spine dynamics, and memory consolidation in mice, finding distinct impacts on neural function and memory.

Transient developmental increase of prefrontal activity alters network maturation and causes cognitive dysfunction in adult mice

The paper shows that increasing prefrontal neuron activity in neonatal mice leads to cognitive deficits in adulthood due to altered network maturation and excitation-inhibition imbalance.

Gamma activity accelerates during prefrontal development

This study shows that gamma oscillations in the prefrontal cortex of mice accelerate during postnatal development, driven by both pyramidal neurons and fast-spiking interneurons.

Bursting mitral cells time the oscillatory coupling between olfactory bulb and entorhinal networks in neonatal mice

The paper investigates the firing patterns of mitral cells in neonatal mice and shows that bursting mitral cells contribute to oscillatory coupling between the olfactory bulb and entorhinal cortex.

Knock-down of hippocampal DISC1 in immune-challenged mice impairs the prefrontal-hippocampal coupling and the cognitive performance throughout development

A Non-negative Measure Of Feature-specific Information Transfer Between Neural Signals

This paper introduces a new measure, Feature-specific Information Transfer (FIT), to quantify feature-specific information flow between neuronal signals and validates it using simulated and real data.

Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice

The paper shows that olfactory bulb activity coordinates with entorhinal circuits in neonatal mice through theta bursts and odor exposure.

Identifying neurophysiological features associated with anesthetic state in newborn mice and humans

The paper uses machine learning to identify electrophysiological features predicting anesthetic depth in newborn mice and human neonates using EEG and intracranial recordings.

Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse

This study shows that intermediate/ventral hippocampal glutamatergic neurons drive prefrontal oscillations in neonatal mice through direct axonal projections and light stimulation.

Microglia inhibition rescues developmental hypofrontality in a mouse model of mental illness

The paper identifies pyramidal neurons in the prefrontal cortex as key elements causing abnormal circuit function in a mouse model of mental illness and shows that microglia inhibition rescues these deficits.

Transient Network Synchrony Of The Developing Medial Entorhinal Cortex

This study shows that developing medial entorhinal cortex (MEC) networks in rodents are synchronously active in spatially-grouped modules, which may help establish spatially-tuned firing properties.