Attention network modulation via tRNS correlates with attention gain

Abstract

Transcranial Random Noise Stimulation (tRNS) can enhance vision in the healthy and diseased brain. Yet, the impact of tRNS on large-scale cortical networks is still unknown. We investigated the impact of tRNS coupled with behavioral training on resting-state functional connectivity and attention. We trained human subjects for four consecutive days on two attention tasks, while receiving tRNS over the intraparietal sulci, the middle temporal areas, or sham stimulation. We measured resting state functional connectivity of nodes of the dorsal and ventral attention network (DVAN) before and after training. We found a strong behavioral improvement and increased connectivity within the DVAN after parietal stimulation only. Crucially, behavioral improvement positively correlated with connectivity measures. We conclude changes in connectivity is a marker for the enduring effect of tRNS upon behavior. Our results suggest that tRNS has strong potential to augment cognitive capacity in healthy individuals and promote recovery in the neurological population.