Short-Term Plasticity Following Motor Sequence Learning Revealed by Diffusion MRI

Abstract

Current non-invasive methods to detect structural plasticity in humans are mainly used to study long-term changes. Diffusion MRI was recently proposed as a novel approach to reveal gray matter changes following spatial navigation learning and object-location memory tasks. In the present work we used diffusion MRI to investigate the short-term neuroplasticity that accompanies sequential motor learning. Following a 45-minutes training session in which participants learned to accurately play a short sequence on a piano keyboard, changes in diffusion properties were revealed mainly in motor system regions such as the premotor cortex and cerebellum. A second learning session taking place immediately afterwards shifted the attention of participants onto timing of key pressing instead of accuracy. This second session induced a different plasticity pattern, demonstrating the dynamic nature of this phenomenon, formerly thought to require months of training in order to be detectable. These results provide us with an important reminder that the brain is an extremely dynamic structure. Furthermore, diffusion MRI offers a novel measure to follow tissue plasticity particularly over short timescales, allowing new insights into the dynamics of structural brain plasticity.