Rhythmic light stimulation elicits multiple concurrent neural responses that separably shape human perception

Abstract

Rhythmic light stimulation offers solutions to innumerable cognitive and neurological disorders. However, like any neuromodulatory technique, responses to rhythmic light stimulation are highly variable, producing challenges in replicating lab-based studies and translating findings to the clinic. Across three MEG/EEG experiments, we show that this variability can, in part, be attributed to rhythmic light stimulation eliciting multiple, coexisting neural responses which have separable impacts on cognition. Specifically, we find that rhythmic light stimulation produces distinct neural responses at the fundamental (f) and second harmonic (2f) frequencies, and that these responses are differentially shaped by endogenous oscillatory dynamics that vary across participants. Importantly, these responses separably contribute to perception, with harmonic gamma-band responses supporting the representation of stimulus-specific information, and the phase of harmonic alpha-band responses causally contributing to near-threshold visual perception. We reproduce these effects across datasets, paradigms, and oscillatory bands, suggesting that the multiplex oscillatory responses elicited by rhythmic light stimulation are a robust and pervasive phenomenon. We propose that the complexity of neural responses to rhythmic stimulation can explain why there is substantial variability between studies using these techniques, and that understanding these complex responses may help advance neuromodulatory technologies for both fundamental and clinical neuroscience. Supplementary MaterialAll supplementary material can be found at the end of this document.