Parietal alpha stimulation causally enhances attentional information coding in evoked and oscillatory activity

Abstract

Selective attention is a fundamental cognitive mechanism that allows people to prioritise task-relevant information while ignoring irrelevant information. Previous research has suggested key roles of parietal evoked potentials and alpha oscillatory responses in spatial attention tasks. However, the informational content of these signals is less clear, and their causal effects on the coding of multiple task elements are yet unresolved. Here, we used concurrent TMS-EEG to causally manipulate parietal alpha power and evoked potentials and investigate their roles in coding multiple task features (where to attend, what to attend to, and visual stimulus) in a selective attention task. First, using EEG-only data, we found that evoked potentials coded all three types of task-relevant information with distinct temporal dynamics, and alpha oscillations carried information regarding both where to attend and what to attend to. Then, we applied rhythmic-TMS (rTMS) at individual alpha frequency over the right intraparietal sulcus (IPS), while concurrently measuring EEG. Compared with control arrhythmic-TMS, alpha rTMS increased alpha power and inter-trial phase coherence and yielded more negative posterior-contralateral evoked potentials. Moreover, alpha rTMS causally and specifically improved multivariate decoding of the information about where to attend (but not what to attend to or feature information) during task performance, with decoding improvements predicting changes in behavioural performance. These findings illuminate the dynamics with which the complementary aspects of a selective attention task are encoded in evoked and oscillatory brain activity. Moreover, they reveal a specific and causal role of IPS-controlled evoked and oscillatory activity in carrying behaviour-driving information about where to focus attention.