Relative evolutionary rate inference in HyPhy with LEISR
Abstract
We introduce LEISR (Likehood Estimation of Individual Site Rates, pronounced \"laser\"), a convenient implementation in HyPhy to infer relative evolutionary rates from protein and nucleotide data. LEISR is based on the popular Rate4Site (1) approach for inferring relative site-wise evolutionary rates from protein data. We extend the original method by allowing for rate inference on both protein and nucleotide data, and we further overcome data-size limitations in Rate4Site. LEISR is available in HyPhy starting with version 2.3.7.
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