Theory of measurement for site-specific evolutionary rates in amino-acid sequences
Dariya K. Sydykova, Claus O. Wilke
The paper develops a theory for measuring site-specific evolutionary rates in amino-acid sequences using maximum likelihood under a mutation-selection model, showing that rates measured relative to a naive exchangeability matrix recover true expected rates.
bioRxiv · Sep 7, 2018 · PreprintEvolutionary Biology