Vitamin D attenuates TNF-α-mediated neurotoxicity and improves functional recovery in experimental intracerebral haemorrhage

Abstract

While the neuroprotective effects of vitamin D (Vit-D) have been demonstrated pre-clinically in a wide range of neurologic conditions, its potential use in the treatment of spontaneous intracerebral hemorrhage (ICH) has not been fully explored. We previously reported that Vit-D could expedite hematoma clearance in experimental ICH by inducing the conversion of M1 to M2 macrophage to enhance erythrophagocytosis1,2. Here, we provide new evidence on the dose-dependent effects of Vit-D on neuronal survival and functional recovery, lending further support for the clinical testing of Vit-D in the management of ICH.