Differences in brain activity during sentence repetition in people who stutter: a combined analysis of four fMRI studies

Abstract

Our understanding of the neural correlates of developmental stuttering benefits from the use of functional MRI (fMRI) during speech production. Despite two decades of research, however, we have reached little consensus. In the current study, we analysed pooled fMRI data from four different studies that used the same sentence reading task and methodological approach. The combined sample included 56 adolescents and adults who stutter and 53 demographically matched typically fluent controls. A sparse-sampling design was used in each study, in which participants spoke during the silent period between measurements of brain activity. Sentence reading evoked activity in both groups across frontal and temporal regions bilaterally. At statistical thresholds corrected for family-wise error, there were no significant group differences. An uncorrected threshold was applied to explore group differences in areas previously identified in earlier fMRI studies on stuttering. People who stutter (PWS) showed greater activity compared with controls in right frontal pole, right anterior insula extending to frontal operculum, left planum temporale, and midbrain, at the level of red nucleus. In contrast, PWS showed lower activity in left superior frontal sulcus, subgenual medial prefrontal cortex, right anterior temporal lobe, and portions of inferior parietal lobe bilaterally including the angular gyrus on the left. Despite pooling data across multiple studies to achieve a relatively large sample, group differences in regions involved in speech-motor control only emerged at an uncorrected voxel-wise threshold. Some of these findings align with previous fMRI studies, such as increased activity in the right anterior insular cortex.