Independent regulation of memory and emotion by selective retrieval

Abstract

Selective retrieval of a target memory often triggers inhibitory control to reduce competition from related traces, a process that induces forgetting of the competing content. It is unknown, however, whether inhibition during selective retrieval specifically targets a competitors episodic representation or instead extends to its affective components. Here we report evidence in humans that selective retrieval of a neutral memory not only diminishes access to the mnemonic content of unpleasant competing memories, but also alters their emotional character. Memory and emotion suppression effects were accompanied by reduced neural activation and weakened representational patterns unique to competing memories in the VTC and amygdala respectively, in an independent fashion. Selective retrieval engaged the left VLPFC, which decreased in activity over repeated retrievals of the same memory, as competition from the unpleasant scene was resolved. This left VLPFC region colocalizes with key prefrontal regions engaged during cognitive reappraisal, suggesting that selective retrievals impact on affective responses may contribute to reappraisals benefits. These findings indicate that inhibitory control during selective retrieval affects both mnemonic and affective representations, providing a novel mechanistic basis for a well-known emotion regulation practice.