Chemical CommunicationsSynthetic BiologyPeer-reviewed journal article
Circularly permuted LOV domain as an engineering module for optogenetic tools
Abstract
We re-engineered a commonly-used light-sensing protein, LOV domain, using a circular permutation strategy to allow photoswitchable control of the C-terminus of a peptide. We demonstrate that the use of circularly permuted LOV domain on its own or together with the original LOV could expand the engineering capabilities of optogenetic tools.
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