A corticostriatal circuit updates subjective beliefs about latent task states

Abstract

Beliefs about states of the world profoundly impact decision-making and learning, but little is known about how neural circuits represent and update beliefs. We performed projection-specific recordings and perturbations from neurons in the orbitofrontal cortex (OFC) projecting to the intermediate or rostral cau-date putamen (CPi/CPr) in rats performing a task with hidden reward states. Stimulating OFC[->]CPi neurons biased rats beliefs towards high reward states. Recordings from optogenetically-tagged OFC[->]CPi neurons showed that they encoded categorical evidence for high reward states, shaped by a saturating non-linearity in neural responses. Downstream neurons could, in principle, decode the full belief distribution over reward states as rats deliberated about deci-sions. Finally, projection-specific perturbations disrupted encoding of hidden states within OFC. These findings reveal the circuit implementation of a core cognitive computation, updating subjective beliefs about abstract latent states of the environment.