Cortical Representation of Pitch Perception in Mice

Abstract

Pitch perception arises from temporal and spectral cues in sound. We hypothesized that mice rely on temporal cues because they have wide auditory filters, resembling humans with hearing loss or cochlear implants. Using computational modeling, behavioral assays, and widefield calcium imaging, we found that the structure of periodotopy in auditory cortex predicts how well mice recognize temporal pitch cues, establishing mice as a robust model for temporal pitch perception.