Differences in Early and Late Pattern-Onset Visual-Evoked Potentials between Self-Reported Migraineurs and Controls

Striped patterns have been shown to induce strong visual illusions and discomforts to migraineurs in the literature. Previous research has suggested that those unusual visual symptoms be linked with the hyperactivity on the visual cortex of migraine sufferers. The present study searched for evidence supporting this hypothesis by comparing the visual evoked potentials (VEPs) elicited by striped patterns of specific spatial frequencies (0.5, 3, and 13 cycles) between a group of 29 migraineurs (17 with aura/12 without) and 31 non-migraineurs. In addition, VEPs to the same stripped patterns were compared between non-migraineurs who were classified as hyperexcitable versus non-hyperexcitable using a previously established behavioural pattern glare task. We found that the migraineurs had a significantly increased N2 amplitude for stimuli with 13 cpd gratings but an attenuated late negativity (LN: 400 - 500 ms after the stimuli onset) for all the spatial frequencies. Interestingly, non-migraineurs who scored as hyperexcitable appeared to have similar response patterns. We proposed that the enhanced N2 could reflect disruption of the balance between parvocellular and magnocellular pathway, which is in support of a grating-induced cortical hyperexcitation mechanism on migraineurs. On the other hand, the attenuation of the late negativity could reflect a top-down feedback mechanism to suppress visual processing of an aversive stimulus.