Precision Functional Neuroimaging Reveals Individually Specific Auditory Responses in Infants

Abstract

Adaptively responding to salient stimuli in the environment is a fundamental feature of cognitive development in early life, which is enabled by the developing brain. Understanding individual variability in how the brain supports this fundamental process is essential for uncovering neurodevelopmental trajectories and potential neurodevelopmental risks. In the present study, we used a precision functional imaging approach to probe activation in response to salient auditory stimuli and its relation to brain functional networks in individual infants. A minimum of 60 minutes of fMRI BOLD data with an auditory oddball paradigm were collected in ten infants with a mean postmenstrual age of 48 weeks. Results demonstrate the feasibility of performing a precision functional imaging study to investigate individual specific responses to salient stimuli in infants. While responses to the auditory oddball were consistent between individuals in auditory processing areas, responses across the rest of the brain differed across individuals in their magnitude and shape. Individual specific response patterns appeared to be relatively stable and differed from other participants response patterns, despite fluctuations across runs. Commonalities and differences between individuals demonstrated in this sample contribute to our understanding of how the developing brain instantiates processing of salient stimuli. Our findings suggest that during early development, early unimodal processing is well conserved across individuals, however subsequent perceptual processing is still being personally defined. In this context, individual specific response patterns could be a promising target for biomarkers of normative brain and cognitive development.