Multiplicative Joint Coding in Preparatory Activity for Reaching Sequence in Macaque Motor Cortex

Abstract

Although motor cortex has been found to be modulated by sensory or cognitive sequences, the linkage between multiple movement elements and sequence-related responses is not yet understood. Here, we recorded neuronal activity from the motor cortex with implanted micro-electrode arrays and single electrodes while monkeys performed a double-reach task that was instructed by simultaneously presented memorized cues. We found that there existed a substantial multiplicative component jointly tuned to impending and subsequent reaches during preparation, then the coding mechanism transferred to an additive manner during execution. Multiplicative joint coding, which also spontaneously emerged in a recurrent neural network trained for double-reach, enriches neural patterns for sequential movement, and might explain the linear readout of elemental movements.