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Evolutionary BiologyTheoretical Population Biology
Peer-reviewed journal article

The TMRCA of general genealogies in populations with deterministically varying size

Alejandro H. WencesiD, Lizbeth Peñaloza, Matthias SteinrückeniD, Arno Siri‐JégousseiD

PDFDOIPreprint

Abstract

We study the time to the most recent common ancestor (TMRCA) of a sample of finite size in a wide class of genealogical models for populations with deterministically varying size. This is made possible by recently developed results on inhomogeneous phase-type random variables, allowing us to obtain the density and the moments of the TMRCA of time-dependent coalescent processes in terms of matrix formulas. We also provide matrix simplifications permitting a more straightforward calculation. With these results, the TMRCA provides an explanatory variable to distinguish different evolutionary scenarios, and to infer model parameters.

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