Matthias Steinrücken

Microevolutionary cophylogeny reflects host-symbiont population dynamics and human mitonuclear interactions

The paper measures microevolutionary cophylogeny between host and symbiont genomes using ancestral recombination graphs and finds variation in mitonuclear cophylogeny across human populations.

General moment closure for the neutral two-locus Wright-Fisher dynamics

This paper introduces a method to close the system of equations for moment dynamics in population genetics under recombination, enabling more accurate numerical computations of genetic diversity and linkage statistics.

A novel expectation-maximization approach to infer general diploid selection from time-series genetic data

This paper introduces an expectation-maximization method to infer general diploid selection from time-series genetic data, finding evidence for selection in six genomic regions from ancient DNA samples.

diplo-locus: A lightweight toolkit for inference and simulation of time-series genetic data under general diploid selection

The paper introduces diplo-locus, a Python toolkit for simulating and inferring parameters from time-series genetic data under diploid selection models.

The TMRCA of general genealogies in populations with deterministically varying size

The paper derives matrix formulas for the density and moments of the TMRCA in time-dependent coalescent processes with varying population size.

Reply to Barton et al: signatures of natural selection during the Black Death

The paper addresses statistical concerns about detecting natural selection during the Black Death using ancient genomic data, reaffirming findings related to immune loci and the ERAP2 variant.

Robust Inference of Population Size Histories from Genomic Sequencing Data

This paper introduces CHIMP, a method for inferring population size histories from genomic data, showing comparable performance to existing methods and improved accuracy in estimating effective population sizes.

Polygenic score accuracy in ancient samples: quantifying the effects of allelic turnover

This paper quantifies how allelic turnover affects polygenic score accuracy in ancient samples using theoretical models and simulations.

Properties of Two-Locus Genealogies and Linkage Disequilibrium in Temporally Structured Samples

The paper derives properties of linkage disequilibrium and haplotype patterns in temporally structured samples, providing insights for analyzing ancient and modern genetic data.

A numerical framework for genetic hitchhiking in populations of variable size

This paper presents a numerical framework to model genetic hitchhiking in populations with variable sizes using the Wright-Fisher diffusion process.

Haplotype-resolved inversion landscape reveals hotspots of mutational recurrence associated with genomic disorders

The paper identifies recurrent inversions in human genomes and links them to genomic disorders through mutational recurrence and structural diversity.

Human Parental Relatedness through Time - Detecting Runs of Homozygosity in Ancient DNA

This paper detects runs of homozygosity in ancient DNA to infer parental relatedness, finding low rates of close unions and a decline linked to agriculture adoption.