Differential reach vector computations in mIPS and PMd as revealed through HD-tDCS

Abstract

Recent neural and behavioural findings provide support that the medial intraparietal sulcus (mIPS) and dorsal premotor (PMd) activity reflect aspects of a kinematic plan for reaching movements. However, it is unclear how these two regions differentially contribute to reach planning. Here, we used high-definition transcranial direct current stimulation (HD-tDCS; 4 x 1 electrode placement; 2 mA for 20 min; 3 cm radius) to investigate the functional roles of mIPS and PMd in the left hemisphere of humans. We examined the changes in endpoint error in reaching task with different initial hand positions and different target locations spanning both visual hemi-fields. Participants completed the task with (stimulation, post-stimulation) and without stimulation (pre-stimulation) of individually fMRI-localized cortical areas mIPS and PMd. We found a significant interaction effect between initial hand position (IHP) and target position on the difference in horizontal endpoint error after cathodal left mIPS stimulation and significant IHP and target position main effects after cathodal left PMd stimulation, suggesting that IHP and target position are not yet integrated into a movement vector at the input of the mIPS, but are integrated in the input of PMd. Hence, these findings reveal a distinction between mIPS and PMd in the stages of movement vector formation for reaching movements and indicate that HD-tDCS is a viable method for perturbing localized cortical activity to elucidate localized cortical function.